Odyssey Life Sciences Capabilities Overview
| PRE-CLINICAL SUPPORT SERVICES |
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| Small Animal Models for TBI-PBBI, CCI, FPI (rats, swine) |
| Small Animal Models for Wound Infections—Wound, Burn, Blast, Polytrauma (waxworm, mice, swine, swine skin explants, bivalve) |
| Small Animal Models for Enteric Infections (mice, guinea pigs, rabbits) |
| Animal Model Experimental Techniques: Intracranial Pressure (ICP), Mean Arterial Pressure (MAP), EKG, Injections (IP, SC, IM, Tail vein), Histopathology, Respiration Analysis (Blood, PBMC, Platelets, CSF) |
| Functional Neurological Testing: Rotarod and Morris Water Maze, Neuro Score |
| Neurological Assays: Seahorse |
| Neurological Biomarker Assessments: Simoa |
| Experience with DNA, RNA, Protein, Toxins, Viruses (including Bacteriophage), Bacteria and Fungi- Isolation, production, purification and characterization |
| DNA and RNA Extraction and Purification |
| Molecular Biology Assays (DNA PCR, RT-PCR, qPCR, Plasmid Cloning, Sequencing) |
| Immunological Assays (Immunoblotting, Immunoprecipitation, ELISA, Western Blot including automated Jess, Biacore, Binding Antibody, Neutralizing Antibody, OPKA) |
| Biochemical Assays |
| X-ray crystallography |
| Light Microscopy (Upright and Inverted) |
| Chemiluminescence and Bioluminescence |
| Spectrophotometry |
| Transmission Electron Microscopy (TEM), including CryoEM |
| Mass Spectrometry |
| Solid-Phase Protein Synthesis |
| Peptide Synthesis |
| Protein Purification (Westphal and Jann Methods) |
| Microfluidization |
| Agarose Gel Electrophoresis |
| SDS-Polyacrylamide Gel Electrophoresis (SDS-PAGE) |
| Silver Staining |
| Giemsa Staining |
| Coomassie Assay |
| BCA Protein Assay |
| Plaque Assay (and purification) |
| Cytotoxicity Assay |
| Enzyme Inhibition Assay |
| Insulin Reduction Assay |
| Biofilm Inhibition Assay |
| Protease Activity Assay |
| Bacteriophage Lysogeny Assay |
| Bacteria Motility Assay |
| PharmacoKinetics/PharmacoDynamics (PK/PD) |
| Host-Range Testing |
| Antimicrobial Checkerboard Assay (Small Molecule, Antibody, Phage) |
| Minimum Inhibitory Concentration (MIC) Testing |
| Myeloperoxidase Staining (MPO) |
| Low Copy Number (LCN) DNA Analysis |
| Slide Agglutination Testing |
| Bacterial Enzymatic Combinatorial Chemistry (BECC) |
| Limulus Amebocyte Lysate (LAL) Assay for Endotoxin Testing |
| High Pressure Liquid Chromatography (HPLC) |
| Ion Metal Affinity Chromatography (IMAC) |
| Imaging (ARANZ, IVIS) |
| Protein Lyophilization |
| Product Formulation |
| Product Stability Studies |
| Bacterial Cell Culture (small scale) and fermentation (large scale- 10L) |
| Human Cell Isolation: PBMC, Platelets |
| Mammalian Cell Culture (PBMC, CHO, HeLa) |
| Sporangiospore Isolation |
| Mammalian Cell Invasion Assays |
| Viral Vector Development (Virus-Like Particles- VLPs) |
| DNA Vector Development and bacterial transformation |
| Organ on a Chip Testing |
| BSL1 and BSL2 |
| Hazardous Material Handling (Chemical and Biological) |
| Biological Sample Management |
| GraphPad Prism Analyses |
| R Analyses |
| Python |
| Bioinformatics (VICTOR, iTOL, Bacphlip, HHPRED) |
| Current Good Laboratory Practices (cGLP) |
| Current Good Manufacturing Practices (cGMP) |
| Vaccine Platform Development |
| Therapeutic and Prophylactic Testing (TBI, Wound, Burn, Blast, Polytrauma, Enteric) |
| CLINICAL INVESTIGATIONS RESEARCH |
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| Protocol Development & Approvals |
| Data Collection |
| Regulatory Compliance & Audit Support |
| Maintenance of Regulatory Binders |
| Subject Enrollment and Consent |
| Subject Follow-Up |
| Biostatistical Analysis |
| Administration of Protocols involving Human Subjects |
| IRB Submissions and Administration |
| Pharmaceutical Support |
| Biomedical Research (Pediatrics, ENT, Family Medicine, Orthopedics, Women’s Health, Emergency Medicine) |
| Current CITI and Good Clinical Practices (GCP) |
| HIPAA |
| RESEARCH SUPPORT SERVICES |
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| Acquisition/Procurement support |
| Administrative Command support |
| Human Resources |
| Financial Analysis |
| Laboratory Management |
| Project Management |
| Program Management |
| Laboratory Procurement |
| Public Affairs |
| Hazardous Material Support |
| IT Help Desk |
| System Administration |
| Technical Writing |
| Equipment Monitoring and Maintenance |
| Coordination and Execution of Support, Development, and Educational Partnership Agreements, as well as Cooperative Research |
| Tracking Training Requirements |